Two sample MR report
ELP5_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | -0.0074610 | 0.0553774 | 0.8957902 |
| Weighted median | 11 | -0.0233187 | 0.0067817 | 0.0005850 |
| Inverse variance weighted | 11 | -0.0250363 | 0.0054033 | 0.0000036 |
| Simple mode | 11 | -0.0223921 | 0.0104672 | 0.0581083 |
| Weighted mode | 11 | -0.0223087 | 0.0099664 | 0.0491376 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4246950 | 9 | 0.9999849 |
| Inverse variance weighted | 0.5263891 | 10 | 0.9999915 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0119237 | 0.0373908 | 0.7570828 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002356 | 0 | TRUE | 0.1461165 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
